2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-A0057AS2
    Gabapentin-d4 hydrochloride 98%
    Gabapentin-d4 hydrochloride is the deuterium labeled Gabapentin hydrochloride (HY-A0057A). Gabapentin hydrochloride is a potent, orally active P/Q type Ca2+ channel blocker. Gabapentin hydrochloride inhibits neuronal Ca2+ influx and reduction of neurotransmitter release. Gabapentin hydrochloride is a GABA analog that can be used to relieve neuropathic pain.
    Gabapentin-d4 hydrochloride
  • HY-B0002BS1
    Ondansetron-d3 1132757-82-4 98%
    Ondansetron-d3 is the deuterium labeled Ondansetron. Ondansetron(GR 38032;SN 307) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.
    Ondansetron-d3
  • HY-B0002BS2
    Ondansetron-13C,d3 2699607-85-5 98%
    Ondansetron-13C,d3 is the 13C- and deuterium labeled Ondansetron.
    Ondansetron-13C,d3
  • HY-B0103AS1
    Fluvoxamine-d4 maleate 98%
    Fluvoxamine-d4 (maleate) is the deuterium labeled Fluvoxamine maleate. Fluvoxamine maleate (DU-23000 maleate) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.
    Fluvoxamine-d4 maleate
  • HY-B0121BS2
    Sumatriptan-d5 98%
    Sumatriptan-d5 is deuterated labeled Sumatriptan (HY-B0121B). Sumatriptan (GR 43175) is an orally active 5-HT1 receptor agonist with IC50s of 7.3 nm, 9.3nm and 17.8 nm for 5-HT1D, 5-HT1B and 5-HT1F receptors, respectively. Sumatriptan can be used for migraine headache research.
    Sumatriptan-d5
  • HY-B0121BS3
    Sumatriptan-d6 formate 98%
    Sumatriptan-d6 (formate) (GR 43175 free base-d6 (formate)) is deuterium labeled Sumatriptan. Sumatriptan (GR 43175) is an orally active 5-HT1 receptor agonist with IC50s of 7.3 nm, 9.3nm and 17.8 nm for 5-HT1D, 5-HT1B and 5-HT1F receptors, respectively. Sumatriptan can be used for migraine headache research.
    Sumatriptan-d6 formate
  • HY-B0161AS1
    Duloxetine-d7 hydrochloride 98%
    Duloxetine-d7 hydrochloride ((S)-Duloxetine-d7 hydrochloride) is the deuterium labeled Duloxetine hydrochloride (HY-B0161A). Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).
    Duloxetine-d7 hydrochloride
  • HY-B0207AS1
    Pyridostigmine-d3 bromide 98%
    Pyridostigmine-d3 (bromide) is the deuterium labeled Pyridostigmine bromide. Pyridostigmine bromide is a parasympathomimetic and a reversible cholinesterase inhibitor.
    Pyridostigmine-d3 bromide
  • HY-B0304AS1
    Dapoxetine-d6 hydrochloride 1246814-76-5 98%
    Dapoxetine-d6 (LY-210448-d6) hydrochloride is the deuterium labeled Dapoxetine hydrochloride. Dapoxetine hydrochloride is a short-acting selective serotonin reuptake inhibitor (SSRI)
    Dapoxetine-d6 hydrochloride
  • HY-B0383AS2
    Almotriptan-d3 benzoate 98%
    Almotriptan-d3 benzoate is deuterated labeled Almotriptan (HY-B0383A). Almotriptan is a selective agonist of 5-HT 1B/1D Receptor. Almotriptan can used in study of migraine attacks.
    Almotriptan-d3 benzoate
  • HY-B0499AS1
    Otilonium-d4 bromide 98%
    Otilonium-d4 (bromide) is deuterium labeled Otilonium (bromide).
    Otilonium-d4 bromide
  • HY-B0524AS1
    Betahistine-13C,d3 dihydrochloride 98%
    Betahistine-13C,d3 (dihydrochloride) is the 13C- and deuterium labeled Betahistine (dihydrochloride). Betahistine dihydrochloride is an orally active histamine H1 receptor agonist and a H3 receptor antagonist. Betahistine dihydrochloride is used for the study of rheumatoid arthritis (RA).
    Betahistine-13C,d3 dihydrochloride
  • HY-B0623AS1
    Ropinirole-d7 hydrochloride 1261396-31-9 98%
    Ropinirole-d7 hydrochloride is the deuterium labeled Ropinirole hydrochloride. Ropinirole (SKF 101468) hydrochloride is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole hydrochloride has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole hydrochloride has no affinity for the D1 receptors. Ropinirole hydrochloride has the potential for Parkinson's disease.
    Ropinirole-d7 hydrochloride
  • HY-B0661AS1
    Tamsulosin-d4 hydrochloride 2518100-55-3 98%
    Tamsulosin-d4 (hydrochloride) is deuterium labeled Tamsulosin (hydrochloride). Tamsulosin hydrochloride ((R)-(-)-YM12617) is an inhibitor of α1-adrenergic receptor. Tamsulosin hydrochloride is used for the research of prostatic hyperplasia. Tamsulosin hydrochloride attenuates abdominal aortic aneurysm growth in animal models.
    Tamsulosin-d4 hydrochloride
  • HY-B1322AS1
    Amodiaquine-d10 hydrochloride 98%
    Amodiaquine-d10 hydrochloride is deuterated labeled Amodiaquine (HY-B1322A). Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect.
    Amodiaquine-d10 hydrochloride
  • HY-N0210S11
    D-Galactose-d2-1 1176791-08-4 98%
    D-Galactose-d2-1 is the deuterium labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
    D-Galactose-d2-1
  • HY-N0210S12
    D-Galactose-13C,d1 370565-96-1 98%
    D-Galactose-13C,d is the deuterium and 13C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
    D-Galactose-13C,d1
  • HY-N0229S11
    L-Alanine-1-13C,15N 141794-74-3 98%
    L-Alanine-1-13C,15N is the 13C- and 15N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
    L-Alanine-1-13C,15N
  • HY-N0229S14
    L-Alanine-15N,d4 98%
    L-Alanine-15N,d4 is the deuterium and 15N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
    L-Alanine-15N,d4
  • HY-N0473S11
    L-Tyrosine-15N,d7 98%
    L-Tyrosine-15N,d7 is the deuterium and 15N-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
    L-Tyrosine-15N,d7
Cat. No. Product Name / Synonyms Application Reactivity